About Aura: At Aura Biosciences, we are developing a new class of therapies to target and destroy cancer cells selectively, while leaving surrounding tissue unharmed – an approach we call molecular surgery. By safely eliminating cancer locally, we can treat early and transform the lives of people with a wide range of cancers that are poorly managed today.
Our lead program in ocular melanoma is designed to remove cancer cells in the back of the eye as a first-line therapy potentially long before the disease progresses and metastasizes to the liver, where it almost always is fatal. Development of a first-in-class treatment option to selectively destroy cancer cells would create the possibility of a cure in this and other cancers where the disease can be detected early.
This role on the Analytical Sciences (AS) team contributes to Aura’s efforts to develop safe and effective therapies using virus-like particle (VLP)-based technologies. This role is expected to spend 60-80% at the bench.
Responsibilities include but are not limited to:
- Experience performing mammalian cell cytotoxicity assays, ELISA based assays, protein quantitation assays, and scientific principles related to cytotoxicity
- Data trending and analysis using logistic fitting methods, including advanced software platforms for statistical analysis and presentation.
- Analytical methodologies relevant to qualitative and quantitative characterization of virus like particles (e.g., UV/Vis, FTIR, Raman, SPR, Octet, NTA, DLS, flow imaging, etc)
- Some experience with Analytical method development and/or method qualification
- Design studies with internal AD and QC, CDMO, and CTL for VLP and small molecule analytical development, characterization, and qualification to support release testing, stability study, and extended characterization
- Author and review technical protocols and reports, assay summaries, study design and protocols, SOPs, etc
- Ensure accurate and complete documentation of any scientific experimental plan, data and report
- Establish and maintain familiarity with contemporary industrial standards, practices, technologies, literature and ways of performing lab studies
Knowledge, Skills & Capabilities:
- In depth understanding and hand on experience in one or more of the following area is required: Cell-Based cytotoxicity assay, ELISA, spectroscopy (UV/Vis, FTIR, Raman), binding affinity (SPR, Octet, etc.), SDS-PAGE, particle analysis (NTA, DLS, flow imaging, etc.)
- Fundamental understanding of assay development, qualification, validation and transfer
- Strong communication, analytical thinking, technical writing and problem-solving skills
- Knowledge of statistical methods for DOE design and data analysis (e.g. JMP), experience with Quality by Design (QbD) is preferred
- Ability to lead problem solving for issues related to analytical development, qualification, and sample testing
- Ability to author and approve comprehensive and accurate protocols/reports
- Ability to select, implement and use appropriate data management concepts and tools
- Ability to function independently, manage priorities and engage/communicate cross functionally across various teams and meet deadlines with a high tolerance for ambiguity
Education & Relevant Work Experience:
- A MSc degree in a relevant scientific discipline e.g. Analytical Chemistry/Biochemistry with 3+ years of industry experience, BSc with 5+ years of industry experience
- Experience in analytical development and testing of antibody-drug conjugate, viral vectors or other biologics (3+ years)
- Experience performing mammalian cell cytotoxicity assays, ELISA based assays and protein quantitation assays (3+ years)
Physical & Travel Requirements:
- Travel to CTLs and CDMOs, as needed (<10%)
Interested? Email a cover letter and a copy of your CV to firstname.lastname@example.org referencing the position description in the subject line.