Sr Scientist, Preclinical Development

About Aura: At Aura Biosciences, we are developing a new class of therapies to target and destroy cancer cells selectively, while leaving surrounding tissue unharmed – an approach we call molecular surgery.  By safely eliminating cancer locally, we can treat early and transform the lives of people with a wide range of cancers that are poorly managed today.

Our lead program in ocular melanoma is designed to remove cancer cells in the back of the eye as a first-line therapy potentially long before the disease progresses and metastasizes to the liver, where it almost always is fatal. Development of a first-in-class treatment option to selectively destroy cancer cells would create the possibility of a cure in this and other cancers where the disease can be detected early.

Position Summary:

This role in the Preclinical Development Team contributes to Aura’s efforts to develop safe and effective therapies using virus-like particle (VLP)-based technologies. This position is expected to require 50-75% of time working at the bench.

Reporting to the Senior Director Preclinical Research & Development, the Senior Scientist will be responsible for the coordination, and execution of internal and external preclinical in-vitro pharmacology studies including assay development and assay optimization. The incumbent will support discovery activities including molecular and cell biology assays as well as coordination of external in-vivo pharmacology studies making significant contributions to project teams.

Responsibilities include but are not limited to:

  • Act as the subject matter expert in preclinical sciences to support in vitro and in vivo pharmacology evaluation of Aura’s pipeline
  • Responsible for the coordination, and execution of internal assay development and optimization activities
  • Support discovery activities including molecular and cell biology assays making significant contributions to project teams
  • Oversee the development and implementation of in vivo and in vitro/cell culture-based pharmacology, biochemical and immunological assays
  • Responsible for various assay platforms, including multi-color flow cytometry, ELISA, western blots, IHC and fluorescent microscopy
  • Author preclinical discovery reports and test methods, manuscripts, and present at scientific conferences
  • Interface with external vendors and CROs regarding in vitro and in vivo pharmacology studies and for the development, qualification, and execution of their assays

Minimum Requirements:

  • Independently be able to set up and maintain an in vitro laboratory including purchasing equipment and work with vendors to set up and calibrate instrumentation
  • Experience with various assay platforms, including multi-color flow cytometry, ELISpot, ELISA, western blots and Luminex. Experience with histopathological staining is preferred but not required
  • Ability to function independently and communicate cross functionally across various teams
  • Be a self-motivated and supportive team member who collaborates effectively across different functions
  • Strong organizational skills with ability to prioritize assigned activities
  • Have strong work ethic, think creatively, and have a team-based orientation
  • Strong communication skills
  • Excellent analytical thinking and problem-solving skills
  • Strong technical writing skills and ability to author and approve comprehensive and accurate protocols/reports
  • Thrive in a fast-paced, results-oriented setting
  • Ability to manage multiple tasks and meet deadlines

Education Requirements:

  • A MSc/PhD degree (PhD preferred) in a relevant scientific discipline e.g. Molecular/Cell Biology, Immunology, Pharmacology
  • PhD with >5 years of industry experience, MSc with >10 years of industry experience

Interested?  Email a cover letter and a copy of your CV to referencing the position description in the subject line.