The most common eye cancers actually don’t start there.

Many cancers that start in other organs (e.g., breast and lung) can metastasize to the eye. Because of the location of these metastases in the choroid, they are diagnosed as choroidal metastases.

Choroidal metastases are a common intraocular malignancy that are caused by multiple primary cancers in the body that metastasize to the eye due to the high blood flow and perfusion that provides an environment receptive to metastases and tumor growth. Approximately 22,000 patients have choroidal metastases globally every year and approximately three quarters of the patients with choroidal metastases have in decreasing order primary breast, lung, gastrointestinal, prostate, skin melanoma and kidney tumors.

AU-011 IN CHOROIDAL METASTASES

AU-011’s mechanism of action does not depend on specific mutations in the genetic profile of the tumor or on the expression of a particular type of growth factor receptor, but rather on the ubiquitously expressed tumor modified HSPGs on the cell membrane of many solid tumors. We believe this makes AU-011 a good potential treatment option for choroidal metastases.